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KMID : 0360220090500010078
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Journal of the Korean Ophthalmological Society
2009 Volume.50 No. 1 p.78 ~ p.84
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Clinical Manifestations of Intraocular Lymphoma
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Suh Min-Hee
Yu Hyeong-Gon
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Abstract
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Purpose: To investigate the clinical features and prognosis of primary intraocular lymphoma (PIOL).
Methods: A retrospective review of medical records was performed in 9 patients who were diagnosed and treated as PIOL in the Department of Ophthalmology, Seoul National University Hospital.
Results: Among patients who were enrolled in the study, 14 eyes were examined. Thirteen eyes (92.9%) showed yellowish subretinal or choroidal infiltrates which is a characteristic finding of PIOL in fundus examination and fluorescein angiography. Three patients presented with ocular symptoms initially, and 5 patients later presented with central nerve system (CNS) involvement. Only 1 patient showed PIOL without CNS involvement. Among 6 patients (9 eyes) that received systemic chemotherapy or ocular irradiation, 5 patients (7 eyes, 77.8%) responded. Among those patients, 3 patients (4 eyes) showed relapse of PIOL. Five patients died during the mean follow-up period of 43.3 months, and the median survival time was 47 months.
Conclusions: The most common characteristic fundus finding of PIOL is subretinal or choroidal infiltration. Ocular irradiation combined with systemic chemotherapy is the first method of treatment, although long-term prognosis is poor.
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KEYWORD
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Primary central nervous system lymphoma, Primary intraocular lymphoma, Prognosis, Subretinal or choroidal infiltration, Vitreous biopsy
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